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E375, Niacin and Gut Health
E375, also known as niacin or vitamin B3, is an approved food additive used as an antioxidant and acidity regulator. It plays a key role in energy metabolism and cellular health. While niacin is essential for the body, its synthetic additive form may have different tolerability for sensitive individuals.
- E375, Niacin is not a FODMAP and does not contain fermentable carbohydrates
- Does not contain histamine or act as a histamine liberator
- No fiber content, so no direct prebiotic or fermentative effect
- Generally well tolerated, but high doses may cause flushing or digestive upset
- Rarely causes allergies or intolerances
E375, Niacin and FODMAP
E375, Niacin is not a FODMAP and does not contain fermentable carbohydrates. This means it is generally safe for people following a low-FODMAP diet or those with irritable bowel syndrome (IBS). Niacin, whether naturally occurring or added as E375, does not contribute to gas, bloating, or other FODMAP-related symptoms.
| FODMAPs | Level | Portion Guidance |
|---|---|---|
|
Monosaccharides (Fructose)
|
Low | — |
|
Disaccharides (Lactose)
|
Low | — |
|
Fructooligosaccharides (Fructans)
|
Low | — |
|
Galactooligosaccharides (GOS)
|
Low | — |
|
Polyols (Mannitol)
|
Low | — |
|
Polyols (Sorbitol)
|
Low | — |
Histamine and E375, Niacin
E375, Niacin does not contain histamine, does not act as a histamine liberator, and does not block the DAO enzyme. Therefore, it is not considered a trigger for histamine intolerance symptoms. Most people with histamine sensitivity can tolerate niacin as a food additive.
| Histamine & Related | Level | Portion Guidance |
|---|---|---|
|
Histamine Level
|
Low |
|
|
Other Biogenic Amines
|
Low |
|
|
Histamine Liberator
|
Low | — |
|
DAO Blocker
|
Low | — |
Digestive Tolerability of E375, Niacin
In typical food additive amounts, E375, Niacin is well tolerated by most people. However, very high doses of niacin, usually from supplements, can cause digestive upset such as nausea, stomach discomfort, or flushing. These effects are rare at the levels used in foods.
Fiber and Prebiotic Effect
E375, Niacin contains no dietary fiber and does not act as a prebiotic. It does not feed beneficial gut bacteria or contribute to stool bulk. Its primary role in food is as an antioxidant and acidity regulator, not as a source of fiber or fermentable substrate.
Allergy and Intolerance to E375, Niacin
Allergic reactions to E375, Niacin are extremely rare. Most people tolerate niacin well, whether it is naturally present in food or added as an additive. If you have a known sensitivity to synthetic vitamins or additives, monitor for any unusual symptoms, but niacin is not a common allergen.
Details
- Absent Wheat / Spelt
- Absent Rye
- Absent Barley
- Absent Oats
Details
- Absent Crabs
- Absent Prawns
- Absent Shrimp
- Absent Lobsters
- Absent Crayfish
Details
- Absent Almonds
- Absent Brazil Nuts
- Absent Cashews
- Absent Hazelnuts
- Absent Macadamia Nuts
- Absent Pecans
- Absent Pistachios
- Absent Walnuts
Details
- Absent Clams
- Absent Mussels
- Absent Octopus
- Absent Oysters
- Absent Snails
- Absent Squid
Sources and Uses of E375, Niacin in Foods
E375, Niacin is added to a range of foods as an antioxidant and acidity regulator, especially in processed products, cereals, and fortified foods. Its synthetic form is used to ensure consistent levels in food manufacturing. The body uses niacin from both natural and synthetic sources in the same way.